In the Center for Nanomedicine research collaboration we are building an interactive simulator that will facilitate virtual experiments in the delivery of chemotherapy to cancerous tumors in the pancreas and liver through nanoscale particles. In the past year we were able to re-construct an anatomically correct human body from MRI data including the vasculature that connects the pancreas and liver. We are currently working on the fluid dynamics simulations for blood flow through the vasculature. This will allow scientists to study blood flow through different sized arteries and veins, witnessing the blood in the bifurcations of the vasculature. We are also building a particle system that will allow the study of nanoscale particle flow within the fluid dynamics simulations. As we receive more data from the experiments of the materials scientists who are building the nanoscale particles, we can simulate the precise geometries and binding equations of the particles, trying various scenarios to discern which shapes will bind better to the sides of the vessels to leak through to the organs where the tumors occur. This research is uniting an interdisciplinary group of nanoscientists that cross physics, biochemistry, chemical engineering, mechanical engineering, and fluid dynamics.
Key faculty, postdoctoral, and graduate student researchers associated with the project: Dr. Pablo Colapinto, John Delaney, Dr. Haru Ji, Qian Liu, Gustavo Rincon, Dr. Graham Wakefield, Dr. Matthew Wright, Professor JoAnn-Kuchera Morin, and Professor Jamey Marth.